Effect of pregnancy on the uterine vasoconstrictor response to exercise in rats
نویسندگان
چکیده
A major maternal adaptation in pregnancy is the large increase in uteroplacental blood flow that supplies the growing fetus with oxygen and nutrients. The impact of gestation on the dynamic uterine vasoconstrictor response to exercise in the rat, a common model for pathophysiological disorders in pregnancy remains unknown. We hypothesized that rats exhibit a robust uterine vasoconstrictor response to acute exercise that is attenuated in late pregnancy. Pregnant (P, N = 12) and nonpregnant (NP, N = 8) rats were instrumented chronically with a ultrasonic transit-time flowprobe and carotid arterial catheter to directly measure uterine artery blood flow (UtBF) and blood pressure (BP), respectively, at day 20 of gestation for 5 min of treadmill exercise (7 m/min; 6% grade). Preexercise UtBF [P, 2.1 (SD1.6) vs. NP, 0.5 (SD0.3) mL/min P < 0.01) and uterine artery conductance (UtC) [P, 2.1(SD1.7) vs. NP, 0.4 (SD0.2) mL/min × mmHg(-1) × 10(-2), P < 0.01] were higher in pregnant rats, whereas preexercise BP was lower in the pregnant rats [P, 111 (SD13) vs. NP, 126 (SD13) mmHg, P = 0.02]. Preexercise heart rate was similar [P, 457 (SD30) vs. NP, 454 (SD42), P = 0.3]. Exercise initiated rapid and sustained decreases in UtBF [Δ-47% (SD12)] and UtC [Δ-49% (SD12)] that were attenuated in the pregnant rats [UtBF, Δ-25% (SD20) and UtC, Δ-30% (SD20), P = 0.02]. The BP and heart rate responses to exercise were unaffected in late pregnancy (interaction term, P = 0.3). In rats, dynamic exercise induces a uterine vasoconstrictor response that is blunted during late gestation, a response that we observed previously in pregnant rabbits.
منابع مشابه
Effect of gestational stage on uterine artery blood flow during exercise in rabbits.
We tested the hypothesis that the uterine artery vasoconstrictor response to graded exercise during early gestation would be similar to the nonpregnant (NP) state and would be attenuated at mid and term gestation. Responses to graded treadmill exercise were measured in six female New Zealand White rabbits in the NP state and at day 10, day 20, and day 28 (term) of gestation. Uterine artery bloo...
متن کاملتأثیر یک دوره تمرین استقامتی شنا بر سطوح القاییهایپوکسی کبد موشهای باردار در معرض مسمومیت کادمیوم
Background and Objective: The physiological changes in liver function in pregnancy are commonly transient and are rarely permanent. HIFs are important to treatment of injuries,inflammation and response to hypoxia. However exercise in pregnancy and some of environmental toxicities can influence HIF levels.The goal of this study was identification of endurance swimming by identifying HIF-1 prot...
متن کاملThe effect of resistance training on PI3K/mTORc1 signaling in left ventricular of diabetes rats
Background: Clinical evidence points to the effective role of genetic factors and intracellular signaling pathways in physiological cardiac hypertrophy. This study aimed to assess the response of PI3K/mTORc1 signaling pathway in cardiac tissue to resistance training in obese diabetic rats. Materials and Methods: For this purpose, 21 male wistar rats (220±20 g) were obese by 6 weeks high fat di...
متن کاملEffect of exercise training and L-arginine supplementation on oxidative stress and left ventricular function in rats with myocardial infarction
Introduction: The aim of the present study was to evaluate the effect of exercise training and L-arginine supplementation on oxidative stress and systolic ventricular function in rats with myocardial infarction (MI). Methods: Four weeks after the surgically-induced MI, 40 male Wistar rats were randomly assigned to the following 4 groups (n=10): MI-sedentary control (Sed) MI-exercise (Ex) MI-...
متن کاملAttenuation of vasoconstrictor response of knee joint blood vessels to (αl- adrenoceptor activation during chronic monoarthritis in rat: The role of nitric oxide
The effect of chronic inflammation induced by complete Freund's adjuvant (CFA) on anterior blood vessels of knee joint and its diameter was studied. Blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in CFA-treated and contralateral knee joints were observed over a 40-day period, using laser Doppler flowmetery (LDF) technique. Unilateral injection of CFA (0.2 ml) increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015